The term Gradius may refer to:
- Gradius — A 1985 action science fiction horizontal shoot-'em-up game.
- Gradius (series) — A series of horizontal shoot-'em-up games by Konami.
- Gradius (planet) — The home world of the Gradian race, which is usually under attack by intergalactic forces (mainly the Bacterian Empire), setting the plot for many games in the series.
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